The main challenges in establishing a medical school in the Republic of Palau include securing appropriate educational resources, recruiting quality faculty, and developing a curriculum that fits local culture and needs.

Ensuring facilities and equipment that meet international medical education standards, as well as providing student support and career development programs, are also significant challenges. Addressing these challenges requires close cooperation with the government, educational institutions, and the medical community.

Currently, there is no university in the Republic of Palau.